[HTML][HTML] Highly prevalent TERT promoter mutations in aggressive thyroid cancers
Abstract Mutations 1 295 228 C> T and 1 295 250 C> T (termed C228T and C250T
respectively), corresponding to− 124 C> T and− 146 C> T from the translation start site in the …
respectively), corresponding to− 124 C> T and− 146 C> T from the translation start site in the …
TERT Promoter Mutations and Their Association with BRAF V600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer
Context: Promoter mutations chr5: 1,295,228 C> T and chr5: 1,295,250 C> T (termed C228T
and C250T, respectively) in the gene for telomerase reverse transcriptase (TERT) have …
and C250T, respectively) in the gene for telomerase reverse transcriptase (TERT) have …
Frequent Somatic TERT Promoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease
Background: TERT encodes the reverse transcriptase component of telomerase, which adds
telomere repeats to chromosome ends, thus enabling cell replication. Telomerase activity is …
telomere repeats to chromosome ends, thus enabling cell replication. Telomerase activity is …
[HTML][HTML] TERT promoter mutations in thyroid cancer
R Liu, M Xing - Endocrine-related cancer, 2016 - erc.bioscientifica.com
The 2013 discovery of Telomerase reverse transcriptase (TERT) promoter mutations chr5,
1,295,228 C> T (C228T) and 1,295,250 C> T (C250T) in thyroid cancer represents an …
1,295,228 C> T (C228T) and 1,295,250 C> T (C250T) in thyroid cancer represents an …
TERT Promoter Mutations in Thyroid Cancer
Two mutations (C228T and C250T) in the promoter region of the telomerase reverse
transcriptase (TERT) have recently been described in different types of cancer including …
transcriptase (TERT) have recently been described in different types of cancer including …
Telomerase in differentiated thyroid cancer: promoter mutations, expression and localization
M Muzza, C Colombo, S Rossi, D Tosi, V Cirello… - Molecular and cellular …, 2015 - Elsevier
Abstract Telomerase-reverse-transcriptase (TERT) promoter mutations have been recently
described in tumors. In the present large series, TERT mutations were found in 12% of …
described in tumors. In the present large series, TERT mutations were found in 12% of …
The age-and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas
T Liu, N Wang, J Cao, A Sofiadis, A Dinets, J Zedenius… - Oncogene, 2014 - nature.com
Telomerase activation through induction of its catalytic component telomerase reverse
transcriptase (TERT) expression is essential for malignant transformation. TERT promoter …
transcriptase (TERT) expression is essential for malignant transformation. TERT promoter …
Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer
F Panebianco, AV Nikitski, MN Nikiforova… - Cancer …, 2019 - Wiley Online Library
Background Reactivation of telomerase reverse transcriptase (TERT) is an important event
in cancer. Two hotspot mutations in the TERT promoter region, c.‐124C> T (C228T) and c …
in cancer. Two hotspot mutations in the TERT promoter region, c.‐124C> T (C228T) and c …
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Background: The role of telomerase reverse transcriptase (TERT) promoter mutations in
differentiated thyroid cancer has been well established. These mutations have a significantly …
differentiated thyroid cancer has been well established. These mutations have a significantly …
[PDF][PDF] TERT promoter mutations and long-term survival in patients with thyroid cancer
TH Kim, YE Kim, S Ahn, JY Kim, CS Ki… - Endocr Relat …, 2016 - scholar.archive.org
TERT promoter mutations are emerging prognostic biomarkers in multiple cancers and are
found in highly aggressive thyroid cancer. Our aim is to investigate the prognostic value of …
found in highly aggressive thyroid cancer. Our aim is to investigate the prognostic value of …