Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function

K Takeda, N Miyahara, YH Rha, C Taube… - American journal of …, 2003 - atsjournals.org
The lung collectin surfactant protein D (SP-D) is an important component of the innate
immune response but is also believed to play a role in other regulatory aspects of immune …

Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans

EN Atochina-Vasserman, C Winkler… - American journal of …, 2011 - atsjournals.org
Rationale: Surfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by
airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have …

Surfactant protein D deficiency influences allergic immune responses

B Schaub, RM Westlake, H He… - Clinical & …, 2004 - Wiley Online Library
Background The collectin surfactant protein D (SP‐D) confers protection against pulmonary
infection and inflammation. Recent data suggest a role for SP‐D in the modulation of allergic …

[引用][C] Surfactant protein D and asthma

A Haczku, G Vass, S Kierstein - Clinical & Experimental Allergy, 2004 - Wiley Online Library
Because of its structural uniqueness, specific localization and functional versatility, the lung
collectin surfactant protein (SP)-D is an important major player of pulmonary immune …

SP‐D and regulation of the pulmonary innate immune system in allergic airway changes

LR Forbes, A Haczku - Clinical & Experimental Allergy, 2010 - Wiley Online Library
The airway mucosal surfaces are constantly exposed to inhaled particles that can be
potentially toxic, infectious or allergenic and should elicit inflammatory changes. The …

IL-4 induces production of the lung collectin surfactant protein-D

Y Cao, JQ Tao, SR Bates, MF Beers… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Surfactant protein (SP)-D is an epithelial cell product of the distal air
spaces that aids uptake and clearance of inhaled pathogens and allergens. Allergic airway …

Surfactant protein D inhibits early airway response in Aspergillus fumigatus‐sensitized mice

VJ Erpenbeck, M Ziegert… - Clinical & …, 2006 - Wiley Online Library
Background The surfactant protein SP‐D has been reported to reduce bronchial hyper‐
responsiveness, blood eosinophilia, and T‐helper type 2 cytokines in models of allergic …

[HTML][HTML] The immunoregulatory roles of lung surfactant collectins SP-A, and SP-D, in allergen-induced airway inflammation

JY Wang, KBM Reid - Immunobiology, 2007 - Elsevier
It has become increasingly evident that pulmonary surfactant proteins, SP-A and SP-D,
present in the alveolar and bronchial epithelial fluid linings, not only play significant …

[HTML][HTML] Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model

C Schleh, BM Rothen-Rutishauser, F Blank… - Respiratory …, 2012 - Springer
Background Allergen-containing subpollen particles (SPP) are released from whole plant
pollen upon contact with water or even high humidity. Because of their size SPP can …

Therapeutic effect of surfactant protein D in allergic inflammation of mite‐sensitized mice

CF Liu, YL Chen, CC Shieh, CK Yu… - Clinical & …, 2005 - Wiley Online Library
Summary Background Surfactant protein D (SP‐D) is involved in the innate immunity within
the lung and may have important roles in modulating the inflammatory process of asthma …