Effects of apixaban compared with warfarin as gain in event-free time–a novel assessment of the results of the ARISTOTLE trial

E Berglund, L Wallentin, J Oldgren… - European Journal of …, 2020 - academic.oup.com
Background A novel approach to determine the effect of a treatment is to calculate the delay
of event, which estimates the gain of event-free time. The aim of this study was to estimate …

Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale

RD Lopes, JH Alexander, SM Al-Khatib, J Ansell… - American heart …, 2010 - Elsevier
Atrial fibrillation (AF) is associated with increased risk of stroke that can be attenuated with
vitamin K antagonists (VKAs). Vitamin K antagonist use is limited, in part, by the high …

Response to letter regarding article,“efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for …

L Wallentin, RD Lopes, M Hanna, L Thomas… - Circulation, 2014 - Am Heart Assoc
We thank Drs Replogle and Pittman for their comments on how to best report and refer to the
results of prospective, randomized, clinical trials. The Apixaban for Reduction in Stroke and …

Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial

SM Al-Khatib, L Thomas, L Wallentin… - European heart …, 2013 - academic.oup.com
Aims It is uncertain whether the benefit from apixaban varies by type and duration of atrial
fibrillation (AF). Methods and results A total of 18 201 patients with AF [2786 (15.3%) with …

Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial

S Halvorsen, D Atar, H Yang… - European heart …, 2014 - academic.oup.com
Aims The risk of stroke in patients with atrial fibrillation (AF) increases with age. In the
ARISTOTLE trial, apixaban when compared with warfarin reduced the rate of stroke, death …

Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE …

C Held, EM Hylek, JH Alexander, M Hanna… - European heart …, 2015 - academic.oup.com
Abstract Aim In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in
Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced the risk of …

Apixaban in patients with atrial fibrillation and prior coronary artery disease: insights from the ARISTOTLE Trial

MC Bahit, RD Lopes, SH Hohnloser, D Wojdyla… - 2012 - Am Heart Assoc
Background: Patients with atrial fibrillation (AF) and coronary artery disease (CAD) are at
high risk for ischemic and bleeding events, and warfarin is known to reduce coronary events …

Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in …

CB Granger, RD Lopes, M Hanna, J Ansell… - American heart …, 2015 - Elsevier
Background We sought to assess the occurrence of events after blinded study drug
discontinuation and transition to open-label vitamin K antagonist (VKA) in ARISTOTLE …

Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised …

RD Lopes, SM Al-Khatib, L Wallentin, H Yang, J Ansell… - The Lancet, 2012 - thelancet.com
Summary Background The Apixaban for Reduction in Stroke and Other Thromboembolic
Events in Atrial Fibrillation (ARISTOTLE) trial showed that apixaban is better than warfarin at …

Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation

L Wallentin, RD Lopes, M Hanna, L Thomas… - Circulation, 2013 - Am Heart Assoc
Background—In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in
Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced stroke and …