Using a model of recreational cocaine consumption, we have determined in four rhesus
monkeys the impact of self-administered cocaine on mesolimbic and sensorimotor striatal …

Studies were conducted to determine the impact of self-administered cocaine on
extracellular striatal dopamine in four rhesus monkeys. The extent to which external cue …

The purpose of this study was to examine the time course of changes in dopamine D1-and
D2-like receptor densities in monkeys self-administering cocaine. Experimentally naı̈ve …

Using in vivo microdialysis, this study attempted to determine whether a neurochemical
predisposition to self-administer cocaine could be identified. Estimated extracellular levels of …

Environmental cues are thought to play a role in drug craving, leading to the high relapse
rate observed in cocaine abusers. Cocaine‐paired cues can reinstate cocaine‐maintained …

Although neuroimaging investigations in human cocaine abusers have provided important
insights into the brain changes that accompany drug use, the interpretation of reports in …

Cocaine amplifies dopaminergic neurotransmission via blockade of presynaptic neuronal
uptake. This action is believed to be a crucial component of cocaine's ability to exert its …

Because most human studies of the neurobiological substrates of the effects of cocaine have
been performed with drug-dependent subjects, little information is available about the effects …

Rationale The transition from infrequent and controlled cocaine use to dependence may
involve enduring changes in neurobiology as a consequence of persistent drug use …

Previous studies utilizing a nonhuman primate model have shown that cocaine self‐
administration in its initial stages is accompanied by alterations in functional activity largely …