Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy

MI McCarthy, E Zeggini - Trends in pharmacological sciences, 2007 - cell.com
Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental
factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 …

Genome-wide association studies in type 2 diabetes

MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …

Insights into the genetic basis of type 2 diabetes

N Kato - Journal of diabetes investigation, 2013 - Wiley Online Library
Type 2 diabetes is one of the most common complex diseases, of which considerable efforts
have been made to unravel the pathophysiological mechanisms. Recently, large‐scale …

Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes

HJ Ng, AL Gloyn - Current diabetes reports, 2013 - Springer
Type 2 diabetes is a global pandemic for which there is currently no disease-modifying
treatment. New and targeted therapeutics are greatly needed, but progress in identifying …

[HTML][HTML] Genetics of type 1 diabetes: what's next?

F Pociot, B Akolkar, P Concannon, HA Erlich, C Julier… - Diabetes, 2010 - ncbi.nlm.nih.gov
The discovery of the association between HLA in the major histocompatibility complex
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …

Perspectives on genetic studies of type 2 diabetes from the genome‐wide association studies era to precision medicine

M Imamura, S Maeda - Journal of Diabetes Investigation, 2024 - Wiley Online Library
Genome‐wide association studies (GWAS) have facilitated a substantial and rapid increase
in the number of confirmed genetic susceptibility variants for complex diseases …

The genetics of type 2 diabetes: what have we learned from GWAS?

LK Billings, JC Florez - Annals of the New York Academy of …, 2010 - Wiley Online Library
Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …

Genome-wide association study for type 2 diabetes: clinical applications

V Lyssenko, L Groop - Current opinion in lipidology, 2009 - journals.lww.com
Genome-wide association study for type 2 diabetes: clinical... : Current Opinion in Lipidology
Genome-wide association study for type 2 diabetes: clinical applications : Current Opinion in …

Type 2 diabetes: genetic data sharing to advance complex disease research

J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …

Genetic risk factors for type 2 diabetes: insights from the emerging genomic evidence

EE Ntzani, FK Kavvoura - Current Vascular Pharmacology, 2012 - ingentaconnect.com
Type-2 diabetes is a complex disease modified by a number of environmental and genetic
factors that contribute at varying degrees to the final phenotype and possibly interact with …