The first step in the decay of some eukaryotic mRNAs is the shortening of the poly (A) tail. To
examine how the transcript body was degraded after deadenylation, we followed the decay …

Decay rates of individual mRNAs in the yeast Saccharomyces cerevisiae can vary by 10-to
20-fold. To determine the basis for the rapid degradation of the mRNA encoded by the yeast …

To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …

Several observations in eukaryotic cells suggest that the processes of translation and mRNA
turnover are interrelated. To understand this relationship, we examined the effects of …

The first step in the decay of several yeast mRNAs is the shortening of the poly (A) tail, which
for the MFA2 transcript triggers decapping and 5′-to-3′ degradation. To understand the …

The pathway of mRNA degradation has been extensively studied in the yeast,
Saccharomyces cerevisiae, and it is now clear that many mRNAs decay by a deadenylation …

DIFFERENCES IN degradation rates among messenger RNAs (mRNAs) contribute
significantly to the control of gene expression in eukaryotes. In this review we will focus on …

In yeast, the major mRNA degradation pathway is initiated by poly (A) tail shortening that
triggers mRNA decapping. The mRNA is then degraded by 5′-to-3′ exonucleolysis. In …

We developed a procedure to measure mRNA decay rates in the yeast Saccharomyces
cerevisiae and applied it to the determination of half-lives for 20 mRNAs encoded by well …

A general pathway of mRNA turnover has been described for yeast in which the 3′ poly (A)
tail is first deadenylated to an oligo (A) length, leading to decapping and subsequent 5 …