We present a microfluidic chip for immobilizing Drosophila melanogaster larvae for high
resolution in vivo imaging. The chip creates a low-temperature micro-environment that …

Drosophila melanogaster is a well-established model organism to understand biological
processes and study human diseases at the molecular-genetic level. The central nervous …

The simple body plan and semitranslucent cuticle of the Drosophila larva allow for imaging
of structures close to the body wall within intact animals. These include sensory neurons …

Live imaging is an important technique for studying cell biological processes, however this
can be challenging in live animals. The translucent cuticle of the Drosophila larva makes it …

Single neuronal imaging of a fully intact Drosophila larva is a difficult challenge for
neurosciences due to the robust digging/burrowing behaviour of the Drosophila larva and …

The Drosophila larva has been used to investigate many processes in cell biology, including
morphogenesis, physiology and responses to drugs and new therapeutic compounds …

Recent improvements in optical imaging, genetically encoded fluorophores and genetic
tools allowing efficient establishment of desired transgenic animal lines have enabled …

With powerful genetics and a translucent cuticle, the Drosophila larva is an ideal model
system for live imaging studies of neuronal cell biology and function. Here, we present an …

Resolution in microscopy—the shortest distance between which objects can be
distinguished from each other—is crucial for our ability to view details of biological samples …

Live imaging is a valuable approach for investigating cell biology questions. The Drosophila
larva is particularly suited for in vivo live imaging because the larval body wall and most …