Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of
adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Mammals have evolved to adapt to differences in oxygen availability. Although systemic
oxygen homeostasis relies on respiratory and circulatory responses, cellular adaptation to …

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …

Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …

Adaptation to hypoxia is regulated by hypoxia‐inducible factor 1 (HIF‐1), a heterodimeric
transcription factor consisting of an oxygen‐regulated α subunit and a constitutively …

Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and
tissue adaption to low oxygen tension. HIF-1, a heterodimer consisting of a constitutively …

The heterodimeric hypoxia‐inducible factor (HIF)‐1 is a master transcriptional regulator of
oxygen homeostasis and a possible target for gene therapy of ischemic disease. Although …

Background Hypoxia inducible factor-1 (HIF-1) is a transcription factor that functions to
maintain cellular homeostasis in response to hypoxia. There is evidence that HIF-1 can also …