Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …

Abstract The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …

Hypoxia inducible factor-1 (HIF-1) is a central component of the oxygen sensing system that
coordinates cellular responses to conditions of decreased oxygen availability. The hypoxia …

The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the
mammalian response to oxygen deficiency. The HIFα regulation in response to hypoxia …

The aims of the present review are to summarize and to discuss the role of hypoxia-
inducible factor-1 (HIF-1) and the expression and functions of vasoactive substances in …

Decreases in oxygen levels are observed in physiological processes, such as development,
and pathological situations, such as tumorigenesis and ischemia. In the complete absence …

Hypoxia inducible factors (HIFs) are master-regulators of cellular responses to hypoxia, and
thus are crucial for survival. HIFs also play a role in regulating cellular processes in β-cells …

Hypoxia-inducible factor 1 (HIF-l) accumulates in the nuclei of mammalian cells exposed to
reduced O2 tension in a time-and O2 concentration-dependent manner. HIF-1 plays an …

Most published studies addressing the role of hypoxia inducible factors (HIFs) in hypoxia-
induced pulmonary hypertension development employ models that may not recapitulate the …

Hypoxia-inducible factors (HIF) are ubiquitous transcription factors regulated by oxygen-
dependent proteolysis, and hence rapidly mount an adaptational response to hypoxia. The …