The α6 nicotinic acetylcholine receptor (nAChR) subunit is involved in nicotine-stimulated
dopamine release in the striatum. It is expressed in brain regions and coexpressed with …

Background Alcohol use disorders (AUD s) are a major public health problem, and the few
treatment options available to those seeking treatment offer only modest success rates …

The α7 nicotinic acetylcholine receptor (nAChR) is highly expressed in different regions of
the brain and is associated with cognitive function as well as anxiety. Agonists and positive …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Neuronal nicotinic receptors are comprised of combinations of α2–9 and β2–4 subunits
arranged to form a pentameric receptor. Currently, the principal central nervous system …

Clinical reports suggest a positive association between fat consumption and the incidence of
hyperactivity, impulsivity and cognitive abnormalities. To investigate possible mechanisms …

The α9α10-subtype of nicotinic acetylcholine receptor (nAChR) has recently garnered
interest in biomedicine and is being pursued as an analgesic target. However, the receptor …

Rationale Recent preclinical data has implicated the α7 nicotinic acetylcholine receptor
(nAChR) as a target in modulating nicotine reward. However, the role of the channel …

INTRODUCTION: The purpose of this study was to test the continuing validity of the
hypothesis that neuropeptide Y (NPY) produced in the brain controls food intake through an …

(E)-5-(Pyrimidin-5-yl)-1, 2, 3, 4, 7, 8-hexahydroazocine (TC299423) is a novel agonist for
nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency …