Although a relative newcomer to the nicotinic acetylcholine receptor (nAChR) family,
substantial evidence suggests that α6 containing nAChRs play a key role in CNS function …

Evidence is emerging that neuronal nicotinic acetylcholine receptors (nAChRs) in the
mesolimbic dopamine (DA) system are involved in mediating the reinforcing effects of …

Nicotine enhances attentional and working memory aspects of executive function in the
prefrontal cortex (PFC) where dopamine plays a major role. Here, we have determined the …

Individuals diagnosed with schizophrenia have an exceptionally high risk for tobacco
dependence. Postmortem studies show that these individuals have significant reductions in …

Nicotinic acetylcholine receptors (nAChRs) are pentameric, ligand-gated, cation channels
found throughout the central and peripheral nervous system, whose endogenous ligand is …

Mesolimbic α6* nicotinic acetylcholine receptors (nAChRs) are thought to have an important
role in nicotine behavioral effects. However, little is known about the role of the various α6 …

Methyllycaconitine (MLA) is the most potent and selective antagonist of the α-bungarotoxin
sensitive neuronal nicotinic acetylcholine receptor (nAChR). In the present study, an …

Agonists and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
(nAChR) are currently being developed for the treatment of cognitive disturbances in …

Purpose The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …

Summary Glucagon-like peptide-1 receptor (GLP-1R) agonists promote nicotine avoidance.
Here, we show that the crosstalk between GLP-1 and nicotine extends beyond effects on …