Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
Gene transactivation and transrepression in myc-driven cancers
M Scafuro, L Capasso, V Carafa, L Altucci… - International journal of …, 2021 - mdpi.com
MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
The quest for targets executing MYC-dependent cell transformation
M Hartl - Frontiers in oncology, 2016 - frontiersin.org
MYC represents a transcription factor with oncogenic potential converting multiple cellular
signals into a broad transcriptional response, thereby controlling the expression of …
signals into a broad transcriptional response, thereby controlling the expression of …
Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis
The MYC oncogene has been implicated in the regulation of up to thousands of genes
involved in many cellular programs including proliferation, growth, differentiation, self …
involved in many cellular programs including proliferation, growth, differentiation, self …
Taking on challenging targets: making MYC druggable
D Horiuchi, B Anderton, A Goga - American Society of Clinical …, 2014 - ascopubs.org
The transcription factor proto-oncogene c-MYC (hereafter MYC) was first identified more
than 3 decades ago and has since been found deregulated in a wide variety of the most …
than 3 decades ago and has since been found deregulated in a wide variety of the most …
The myc oncogene: MarvelouslY complex
SK Oster, CSW Ho, EL Soucie, LZ Penn - 2002 - Elsevier
The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …
points and, in a permissive environment, rapidly accelerates the affected clone through the …
The Myc oncoprotein as a therapeutic target for human cancer
M Vita, M Henriksson - Seminars in cancer biology, 2006 - Elsevier
Myc expression is deregulated in a wide range of human cancers and is often associated
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …
Analysis of genomic targets reveals complex functions of MYC
MYC is overexpressed by many human tumour types and has been shown to regulate cell
functions that are required for tumorigenesis. It is not clear, however, which of its target …
functions that are required for tumorigenesis. It is not clear, however, which of its target …
MYC function and regulation in physiological perspective
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …
that regulates almost every physiological process in a cell including cell cycle, proliferation …