The physiologic functions of histamine have been recognized for more than 100 years, yet
new roles are still being uncovered. Most importantly, a newly discovered receptor of the …

The discovery of the histamine H4 receptor has added a new chapter to the century of
extensive biogenic amine research. The human histamine H4 receptor is mainly expressed …

Histamine has a key role in allergic inflammatory conditions. The inflammatory responses
resulting from the liberation of histamine have long been thought to be mediated by the …

Histamine exerts its actions through four known receptors. The recently cloned histamine
receptor, H4R, has been shown to have a role in chemotaxis and mediator release in …

The field of histamine research has progressed far from a century ago when the first
biological functions of histamine were identified. It is now known that histamine function is …

Histamine and antihistamines are so deeply woven into the fabric of allergic diseases that it
is sometimes difficult to see how this field could advance beyond our current, potent …

All 4 known histamine receptors (H1R, H2R, H3R and H4R) have been used or proposed as
therapeutic targets for varied diseases. This article reviews the recent progress in …

The synthesis and the identification of histamine marked a milestone in both
pharmacological and immunological research. Since Sir Henry Dale and Patrick Laidlaw …

Antagonists for the Histamine H 1 receptor have been on the market for decades and
continue to be successfully used in the treatment of a variety of allergic conditions. The …

Histamine and the histamine receptors are important regulators of a plethora of biological
processes, including immediate hypersensitivity reactions and acid secretion in the stomach …