The use of human immunodeficiency virus vectors for gene therapy is hampered by concern
over their safety. This concern might be ameliorated, in part, if the viral accessory genes and …

Lentiviruses infect both dividing and nondividing cells. In this study we characterized a
lentiviral vector system consisting of a packaging vector (pHP) and a transducing vector …

ABSTRACT A number of human immunodeficiency type 1 (HIV-1)-based vectors have
recently been shown to transduce nondividing cells in vivo as well as in vitro. However, if …

In contrast to oncoviruses, lentiviruses do not require target cell division for integration into
the host genome. Lentiviral vectors can therefore expand the spectrum of target cells …

Vectors derived from human immunodeficiency virus (HIV) are highly efficient vehicles for in
vivo gene delivery. However, their biosafety is of major concern. Here we exploit the …

Genetic modification of T lymphocytes holds great potential for treatments of cancer, T cell
disorders and AIDS. While in the past recombinant murine retroviruses were the vectors of …

Introduction 2.1. Virus-mediated gene therapy systems 3. The biology of lentiviral infection
3.1. Molecular aspects of lentiviral infection 3.1. 1. Structural genes of HIV-1 3.1. 2 …

Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a
recent development in the field of gene therapy. A key property of HIV-1-derived vectors is …

Lentiviral vectors based on human immunodeficiency virus type 1 (HIV-1) possess the ability
to deliver exogenous genes to both dividing and nondividing cells and to subsequently …

The development of gene transfer vectors from lentiviruses, such as the human
immunodeficiency virus 1 (HIV-1), has opened exciting perspectives for the genetic …