TNF-α and-β gene polymorphisms in multiple sclerosis: a highly significant role for determinants in the first intron of the TNF-β gene

JAM Fernandes Filho, CA Vedeler, KM Myhr… - …, 2002 - Taylor & Francis
Tumor necrosis factor (TNF)-f and TNF-g are proinflammatory cytokines that have been
implicated in the pathogenesis of several autoimmune diseases. The aim of this …

The polymorphisms of the TNF-α gene in multiple sclerosis?—a meta-analysis

L Xu, W Yuan, H Sun, X Zhang, X Jia, C Shen… - Molecular biology …, 2011 - Springer
The association between multiple sclerosis (MS) and tumor necrosis factor-alpha gene (TNF-
α) polymorphisms has been analyzed in several studies, but conflicting results have been …

TNF‐α promoter polymorphisms in multiple sclerosis: no association with− 308 and− 238 alleles, but the− 857 alleles in associated with the disease in Turkish patients

A Akcali, S Pehlivan, M Pehlivan… - International journal …, 2010 - Wiley Online Library
Dysregulation in the expression of pro‐and anti‐inflammatory cytokines is one of the
milestones in multiple sclerosis (MS) development and progression. Tumour necrosis factor …

TNF-α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients

TWJ Huizinga, RGJ Westendorp, ELEM Bollen… - Journal of …, 1997 - Elsevier
TNF-α production in whole blood cultures upon stimulation with LPS was determined in 179
individuals from 61 families in order to characterise the magnitude of inherited differences in …

Gene polymorphism at position–308 of the tumor necrosis factor α promotor is not associated with disease progression in multiple sclerosis patients

M Mäurer, N Kruse, R Giess, K Kyriallis, KV Toyka… - Journal of …, 1999 - Springer
Tumor necrosis factor-α (TNFα) is a pluripotent proinflammatory cytokine and is thought to
play an important role in the inflammatory process of multiple sclerosis (MS). AG→ A …

TNF-α and TNF-β gene polymorphisms in systemic sclerosis

JP Pandey, F Takeuchi - Human immunology, 1999 - Elsevier
Tumor necrosis factor (TNF)-α and TNF-β, mediators of inflammatory responses, have been
implicated in the pathogenesis of autoimmune diseases. The aim of this investigation was to …

Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case–control cohort

S Hoffjan, A Okur, JT Epplen… - International journal …, 2015 - Wiley Online Library
Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been
implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF 1A …

Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis

R Ehling, C Gassner, A Lutterotti… - Tissue …, 2004 - Wiley Online Library
Common genetic variants have been shown to influence disease susceptibility, disease
course, or both in multiple sclerosis (MS). Several studies have suggested a role for tumor …

A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis

D Wingerchuk, Q Liu, J Sobell, S Sommer… - Neurology, 1997 - AAN Enterprises
Tumor necrosis factor alpha (TNFα) expression in enhanced in patients with active MS and
other inflammatory disease. A guanine-to-adenine polymorphism at position-308 of the …

Decreased frequency of the tumor necrosis factor α–308 allele in Serbian patients with multiple sclerosis

J Drulović, D Popadić, Š Mesaroš, I Dujmović… - European …, 2003 - karger.com
Tumor necrosis factor (TNF) α has been considered the prototypic cytopathogenic cytokine
in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant …