Synopsis Nilvadipine, a calcium antagonist of the dihydropyridine class, selectively blocks
calcium channels in vascular smooth muscle. Compared with nifedipine, the prototype of the …

Nilvadipine is a new calcium antagonist of the the dihydropyridine group. Owing to its high
receptor affinity, nilvadipine blocks L-type calcium channels in vascular muscle cells. This …

Nilvadipine is absorbed rapidly and completely and its absolute bioavailability is about 14–
19% because of its high first-pass metabolism. Maximum plasma levels and the extent of …

Nicardipine is a water soluble calcium channel antagonist, with predominantly vasodilatory
actions. Intravenous (IV) nicardipine (Cardene® IV), which demonstrates a relatively rapid …

Nicardipine hydrochloride (HCl), a new calcium channel-blocking agent classified with the
dihydropyridine derivatives (54), is undergoing clinical investigation in the United States and …

The pharmacokinetics of nilvadipine, a new antihypertensive and antianginal drug, were
examined in healthy male volunteers. In a Latin square, three‐way crossover design with a …

Synopsis Nicardipine is a second generation dihydropyridine calcium antagonist which
selectively inhibits vascular smooth muscle contraction. In elderly patients, the drug Has …

Eighty‐four patients with diastolic blood pressure ranging from 100–115 mm Hg were
randomized into a multicenter, parallel, double‐blind, placebo‐controlled, dose response …

The article presents an overview of the pharmacology and pharmacokinetics of Nicardipine.
Nicardipine is an antagonist of the L-type Calcium ion channel, which demonstrates greater …

A new generation of dihydropyridine calcium antagonists which are related structurally to
nifedipine is undergoing clinical investigation. Among these newer agents, nicardipine and …