It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …

Major depression, whose biological origins have been difficult to grasp for decades, might
result from a disturbance in neuronal plasticity. New theories begin to consider a …

Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the
population at least once in their lifetime, with huge costs for society. Neurobiological …

Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Previously, authors have reviewed the evidence pertaining to a wide range of
neurochemical, neuroendocrine, neurophysiological, and structural correlates of …

The birth of new neurons, or neurogenesis, in the hippocampal formation has been
demonstrated throughout the lifetime of multiple species including humans. A major finding …

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular
zone of the dentate gyrus is regulated negatively by stressful experiences and positively by …

In a novel theory, a failure of adult hippocampal neurogenesis has been proposed to
provide the biological and cellular basis of major depression. The as yet unresolved function …

Major depressive disorder (MDD) is a debilitating and complex psychiatric disorder that
involves multiple neural circuits and genetic and non-genetic risk factors. In the quest for …

The waning and waxing of neurogenesis in brain areas such as the dentate gyrus is
proposed as a key factor in the descent into and recovery from clinical depression …