When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5
mM KCl (K5) caspase‐3 and caspase‐8, but not caspase‐1 or caspase‐9, activities are …

Several signaling pathways are differentially activated during apoptotic cell death. We have
previously found that during apoptotic death of cerebellar granule neurons (CGN) induced …

We investigate the death route induced by potassium depletion in cerebellar granule cells in
0–15 h time range and study whether and how mutual relationship occurs between the cell …

Programmed cell death (PCD) has been defined as an active, controlled process in which
cells participate in their own demise. Apoptosis, or type I PCD, has been widely …

Molecular mechanisms of neuronal cell death are still largely unknown. In the present study,
the signal transduction pathway of cell death in cerebellar granule neurons was examined …

Apoptosis is characterized by chromatin condensation, phosphatidylserine translocation,
and caspase activation. Neuronal apoptotic death involves the participation of reactive …

We have investigated the role of reactive oxygen species (ROS) in cell death induced by
ischemia or application of the excitatory amino acid agonist, N-methyl-D-aspartate (NMDA) …

Cerebellar granule neurons undergo apoptosis when deprived of chronic depolarization;
serum deprivation has not been considered as a trigger of apoptosis in this culture. Here we …

SERUM and potassium withdrawal-induced cell death of cerebellar granule cells is one of
the most popular models used for studying neuronal apoptosis in vitro, and it is generally …

Apoptosis is one type of programmed cell death responsible for the physiological elimination
of various cell populations during development (Wyllie, 1988). It has been estimated that up …