Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis

AL Mora, E Torres-González, M Rojas… - American journal of …, 2006 - atsjournals.org
The etiology of idiopathic pulmonary fibrosis (IPF) is unknown. Because viral pathogenesis
of IPF has been suggested, we have established a murine model of progressive pulmonary …

Lung infection with γ-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

AL Mora, CR Woods, A Garcia, J Xu… - … of Physiology-Lung …, 2005 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic lung disease of unknown
etiology. A viral pathogenesis in IPF has been suggested since> 95% of IPF patients have …

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-γ receptor–deficient mice

AL Mora, E Torres-González, M Rojas, J Xu… - American journal of …, 2007 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder
of unknown cause. Several studies suggest an association between Epstein-Barr virus …

Latent herpesvirus infection augments experimental pulmonary fibrosis

KM Vannella, TR Luckhardt, CA Wilke… - American journal of …, 2010 - atsjournals.org
Rationale: No effective treatment exists for idiopathic pulmonary fibrosis, and its
pathogenesis remains unclear. Accumulating evidence implicates herpesviruses as …

Right place, right time: the evolving role of herpesvirus infection as a “second hit” in idiopathic pulmonary fibrosis

JA Kropski, WE Lawson… - American Journal of …, 2012 - journals.physiology.org
Over the course of the past decade, increasing evidence has implicated alveolar epithelial
cell injury and dysfunction in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Genetic …

Viruses as co-factors for the initiation or exacerbation of lung fibrosis

KM Vannella, BB Moore - Fibrogenesis & tissue repair, 2008 - Springer
Idiopathic pulmonary fibrosis (IPF) remains exactly that. The disease originates from an
unknown cause, and little is known about the mechanisms of pathogenesis. While the …

Viral infection and aging as cofactors for the development of pulmonary fibrosis

PK Naik, BB Moore - Expert review of respiratory medicine, 2010 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown origin and progression that
primarily affects older adults. Accumulating clinical and experimental evidence suggests that …

Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus

TR McMillan, BB Moore, JB Weinberg… - American journal of …, 2008 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis is a progressive disease with high mortality.
Although most patients have a slow, progressive course, some patients will have an acute …

Viruses in idiopathic pulmonary fibrosis. Etiology and exacerbation

BB Moore, TA Moore - Annals of the American Thoracic Society, 2015 - atsjournals.org
Viral infections are important contributors to exacerbation of asthma and chronic obstructive
pulmonary disease; however, the role of viruses in the pathogenesis of idiopathic pulmonary …

Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis

E Torres-González, M Bueno, A Tanaka… - American journal of …, 2012 - atsjournals.org
The incidence of idiopathic pulmonary fibrosis (IPF) increases with age. The mechanisms
that underlie the age-dependent risk for IPF are unknown. Based on studies that suggest an …