More efficacious treatment regimens are needed for tuberculosis, however, drug
development is impeded by a lack of reliable biomarkers of disease severity and of …

The defining pathology of tuberculosis is the granuloma, an organized structure derived from
host immune cells that surrounds infecting Mycobacterium tuberculosis. As the location of …

Recurrent tuberculosis (TB) continues to be a significant problem and is an important
indicator of the effectiveness of TB control. Recurrence can occur by relapse or exogenous …

Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the
host biomarkers appears to play a significant role. The currently available diagnostic …

Lungs are directly exposed to the air, have enormous surface area, and enable gas
exchange in air-breathing animals. They are constantly 'attacked'by microbes from both …

The decision to treat active tuberculosis (TB) is dependent on microbiological tests for the
organism or evidence of disease compatible with TB in people with a high demographic risk …

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …

A unique hallmark of tuberculosis is the granulomatous lesions formed in the lung.
Granulomas can be heterogeneous in nature and can develop a necrotic, hypoxic core …

Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …

Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely
successful pathogen that adapts to survive within the host. During the latency phase of …