Structural basis of T‐cell specificity and activation by the bacterial superantigen TSST‐1
B Moza, AK Varma, RA Buonpane, P Zhu… - The EMBO …, 2007 - embopress.org
Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T‐
cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines …
cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines …
A novel loop domain in superantigens extends their T cell receptor recognition site
Superantigens (SAGs) interact with host immune receptors to induce a massive release of
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes
Superantigens (SAGs) aberrantly alter immune system function through simultaneous
interaction with lateral surfaces of MHC class II molecules on APCs and with particular …
interaction with lateral surfaces of MHC class II molecules on APCs and with particular …
[HTML][HTML] The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation
M Saline, KEJ Rödström, G Fischer, VY Orekhov… - Nature …, 2010 - nature.com
Superantigens (SAgs) are bacterial toxins that interact with immunoreceptors, T cell receptor
(TCR) and major histocompatibility complex (MHC) class II, conventionally through the …
(TCR) and major histocompatibility complex (MHC) class II, conventionally through the …
Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …
The structural basis of T cell activation by superantigens
▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …
Structures of two streptococcal superantigens bound to TCR β chains reveal diversity in the architecture of T cell signaling complexes
Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an
overstimulation of T cells associated with human disease. SAGs interact with several …
overstimulation of T cells associated with human disease. SAGs interact with several …
So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes
EJ Sundberg, Y Li, RA Mariuzza - Current opinion in immunology, 2002 - Elsevier
Superantigens (SAGs) elicit massive T-cell proliferation through simultaneous interaction
with MHC and TCR molecules. SAGs have been implicated in toxic shock syndrome and …
with MHC and TCR molecules. SAGs have been implicated in toxic shock syndrome and …
The T cell receptor β-chain second complementarity determining region loop (CDR2β) governs T cell activation and Vβ specificity by bacterial superantigens
AKMN Rahman, DA Bonsor, CA Herfst, F Pollard… - Journal of Biological …, 2011 - ASBMB
Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …
Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization
The protein toxins known as superantigens (SAgs), which are expressed primarily by the
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
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