Silencing of GRHL2 induces epithelial‑to‑mesenchymal transition in lung cancer cell lines with different effects on proliferation and clonogenic growth

N Kawabe, K Matsuoka, K Komeda… - Oncology …, 2023 - spandidos-publications.com
Abstract Grainyhead‑like 2 (GRHL2) is a transcription factor that suppresses epithelial‑to‑
mesenchymal transition (EMT). It has been previously shown that GRHL2 can confer both …

Diverse expression patterns of the EMT suppressor grainyhead‐like 2 (GRHL 2) in normal and tumour tissues

S Riethdorf, S Frey, S Santjer… - … Journal of Cancer, 2016 - Wiley Online Library
The transcription factor grainyhead‐like 2 (GRHL2) plays a crucial role in various
developmental processes. Although GRHL2 recently has attracted considerable interest in …

[HTML][HTML] GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer

X Pan, R Zhang, C Xie, M Gan, S Yao… - American journal of …, 2017 - ncbi.nlm.nih.gov
The transcription factor, Grainyhead-like 2 (GRHL2), is involved in wound healing,
epidermal integrity, and epithelial-to-mesenchymal transition (EMT) in various biological …

EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer

Y He, M Gan, Y Wang, T Huang, J Wang, T Han… - Cell Death & …, 2021 - nature.com
Abstract Grainyhead-like 1 (GRHL1) is a transcription factor involved in embryonic
development. However, little is known about the biological functions of GRHL1 in cancer. In …

[HTML][HTML] Grainyhead-like 2 promotes tumor growth and is associated with poor prognosis in colorectal cancer

Y Quan, M Xu, P Cui, M Ye, B Zhuang, Z Min - Journal of Cancer, 2015 - ncbi.nlm.nih.gov
GRHL2 was implicated in regulating cancer development. Our previous study demonstrated
that knockdown GRHL2 in colorectal cancer (CRC) cells inhibited cell proliferation by …

Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression

X Xiang, ZB Deng, X Zhuang, S Ju, J Mu, H Jiang… - PloS one, 2012 - journals.plos.org
Until now the essential transcription factor that determines the epithelial phenotype of breast
cancer has not been identified and its role in epithelial-to-mesenchymal transition (EMT) and …

GRHL2 expression functions in breast cancer aggressiveness and could serve as prognostic and diagnostic biomarker for breast cancer

X Bai, Y Li, Y Li, F Li, N Che, C Ni… - Clinical Medicine …, 2022 - journals.sagepub.com
Background: Breast cancer (BC) is the most frequent malignancy in women worldwide and
the leading cause of female cancer–associated death in the world. Grainyhead-like 2 …

Suppressor gene GRHL1 is associated with prognosis in patients with oesophageal squamous cell carcinoma

M Li, Z Li, X Guan, Y Qin - Oncology Letters, 2019 - spandidos-publications.com
Grainyhead like transcription factor 1 (GRHL1) is among the key family genes encoding
transcription factors that serve important roles in inhibiting tumor cell clone growth …

Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer

J Xiang, X Fu, W Ran, Z Wang - Oncogenesis, 2017 - nature.com
Metastasis is one of the typical features of malignancy that significantly increases cancer-
related mortality. Recent studies have shown that epithelial–mesenchymal transition (EMT) …

Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes

FC Lammert, J Pannhausen, E Noetzel… - Molecular … - Wiley Online Library
The effect of grainyhead‐like transcription factor 3 (GRHL3) on cancer development
depends on the cancer subtypes as shown in tumor entities such as colorectal or oral …