Objective The purpose of this study was to detect the expression of GRHL2 in colorectal
cancer (CRC) tissues, and to assess the relationship between GRHL2 expression and …

Purpose GRHL2 played important roles in different cancers. In this study, we aimed to
investigate the roles of GRHL2 in bladder cancer. Methods The immunohistochemistry …

Introduction GRHL1 belongs to the family of Grainyhead-like (GRHL). Previous studies have
shown that dysregulation of growth and survival pathways is associated with the GRHL …

Background & Aims Esophageal squamous cell carcinoma (ESCC) is an aggressive
malignancy with a poor long-term prognosis. The molecular mechanisms underlying the …

Epithelial–mesenchymal transition (EMT) in carcinoma cells enhances malignant
progression by promoting invasion and survival. EMT is induced by microenvironmental …

Cancer stem cell-like phenotype is critical for tumor formation and treatment resistance.
FGFR1 is found to be amplified in non-small cell lung cancer, particularly in the lung …

Trichostatin A (TSA) is a histone deacetylase inhibitor and a potential therapeutic for various
malignancies. The in vivo effect of TSA, however, has not been investigated in a transgenic …

Background: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a
critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN …

Glioblastoma (GBM) tumor cells exhibit mesenchymal properties which are thought to play
significant roles in therapeutic resistance and tumor recurrence. An important question is …

Invasive urothelial carcinomas of the bladder (UCB) characteristically show a loss of
differentiation markers. The transcription factor Grainyhead-like 3 (GRHL3) plays an …