Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2] of Igs by over a
decade and was for a time the only direct way of analyzing their 3–D molecular structure …

This book provides comprehensive up-to-date information on the structure and function of
immunoglobulins. It describes the basic features of these molecules, which assists the …

Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They
can be separated functionally into variable domains that bind antigens and constant …

Publisher Summary This chapter presents the results obtained in the investigation of the
three-dimensional structure of a human Fab´ fragment currently. The chapter explores …

The steady flow of fresh data on antibody structure and interactions has continued. Recent
results have also extended the scope of the available structural information to cover other …

Publisher Summary This chapter reviews studies on the higher levels of organization in
immunoglobulin molecules such as their size and shape as well as the more intimate …

Determination of the primary structure of immunoglobulin proteins provides information that
can be used to extend our knowledge of the structural relationship between different classes …

The techniques of X-ray crystallography have been successfully applied to the study of
complex biological polymers such as nucleic acids and proteins. These studies have …

The immune system in man is com posed of cooperating cellular and humoral components.
Each is con cerned with protecting the integrity and safety of the body from invas ive …

This first volume of the Annual Review of Immunology will appear just 50 years after I began
working in immunochemistry in Michael Heidelberger's laboratory at Columbia University'S …