Antifungal drug discovery: something old and something new

A Butts, DJ Krysan - 2012 - journals.plos.org
Invasive fungal infections are devastating. Despite state-of-theart antifungal therapy, the
mortality rates for invasive infections with the three most common species of human fungal …

Antifungal drug development: challenges, unmet clinical needs, and new approaches

T Roemer, DJ Krysan - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …

Antifungal drugs: the current armamentarium and development of new agents

N Robbins, GD Wright, LE Cowen - Microbiology spectrum, 2016 - Am Soc Microbiol
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Antifungal pipeline

TP McCarty, PG Pappas - Frontiers in cellular and infection …, 2021 - frontiersin.org
In many ways, fungal diseases are forgotten or neglected. Given the significantly lower
frequency compared to similar bacterial etiologies across the spectrum of infectious …

How urgent is the need for new antifungals?

AG Stewart, DL Paterson - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction: Invasive fungal infection carries a high morbidity, mortality and economic cost.
In recent times, a rising incidence of fungal infection and antifungal resistance is occurring …

Potential targets for the development of new antifungal drugs

H Su, L Han, X Huang - The journal of antibiotics, 2018 - nature.com
In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …

Current and future antifungal therapy: new targets for antifungal agents

VT Andriole - Journal of Antimicrobial Chemotherapy, 1999 - academic.oup.com
Invasive fungal infections are a major problem in immunocompromised patients. The recent
expansion of antifungal drug research has occurred because there is a critical need for new …

Novel agents and drug targets to meet the challenges of resistant fungi

MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

The antifungal pipeline for invasive fungal diseases: what does the future hold?

CF Neoh, W Jeong, DCM Kong… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction Over the last two decades, we have experienced pressing needs for new
additions to the antifungal armamentarium given the emergence of resistant fungi, the …

[HTML][HTML] Current and future antifungal therapy: new targets for antifungal therapy

VT Andriole - International journal of antimicrobial agents, 2000 - Elsevier
Invasive fungal infections will continue to cause major complications in
immunocompromized patients. At the moment, the expansion of antifungal drug research …