OBJECTIVE: Nicotine is a highly addictive substance, and cigarette smoking is a major
cause of premature death among humans. Little is known about the neuropharmacology …

OBJECTIVE: The effects of acute nicotine administration and smoking on brain function were
investigated in two studies, with the primary goal of identifying neural systems that mediate …

To elucidate the neural correlates of cognitive effects of nicotine, we examined behavioral
performance and blood oxygenation level-dependent regional brain activity, using functional …

The present paper proposes a model for the identification and the validation of brain
processes and mechanisms underlying smokers' cue reactivity. Smoking behaviour is …

While most cigarette smokers endorse a desire to quit smoking, only 14–49% will achieve
abstinence after 6 months or more of treatment. A greater understanding of the effects of …

Understanding nicotine's neurobiological and cognitive mechanisms may help explain both
its addictive properties and potential therapeutic applications. As such, functional MRI was …

Context Understanding the mechanisms underlying nicotine addiction to develop more
effective treatment is a public health priority. Research consistently shows that nicotine …

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will
achieve abstinence after 6 months or more of treatment. A greater understanding of the …

Nicotine has been shown to have effects on anxiety and depression in both human and
animal studies. These studies suggest that nicotinic acetylcholine receptors (nAChRs) can …

Rationale Substances of misuse (such as nicotine) are associated with increases in
activation within the mesocorticolimbic brain system, a system thought to mediate the …