The exact mechanisms responsible for the progression of heart failure remain unclear. We
investigated the in vivo relationship between the incidence of apoptotic cell death and left …

Various alterations in molecular and cellular events have been considered as possibly
contributing to the cardiac remodelling that occurs during the transition from compensated …

Objective There are two phenotypes of heart failure, systolic failure and isolated diastolic
heart failure with preserved left ventricular systolic function. Although isolated diastolic heart …

Background—Left ventricular hypertrophy (LVH) represents both an adaptive response to
increased cardiac work load and a precursor state of heart failure. Recent evidence linked …

This study examined sex differences in the regulation of pro-and anti-apoptotic proteins in
cardiac hypertrophy and heart failure due to volume overload induced by arteriovenous (AV) …

BACKGROUND:: Cardiomyocyte apoptosis is believed to occur in hypertension. Isolated
myocyte data from spontaneously hypertensive heart failure (SHHF) rats, however, suggest …

Correlation of cardiomyocyte apoptosis with duration of hypertension, severity of
hypertension and caspase‑3 expression in hypertensive rats was analyzed. Sixty male …

New Findings What is the central question of this study? Prior studies failed to address the
role of sex in modifying the pathophysiology and response to therapy in heart failure with …

BACKGROUND: Cardiomyocyte apoptosis is implicated in the pathogenesis of heart failure
and mitochondria play an important role in this mode of cell death. In this study, activity of the …

The transition from compensated hypertrophy to failure in spontaneously hypertensive rats
(SHR) of advanced age is associated with a marked increase in collagen, a reduction in …