Peroxisome development is a dynamic process that may involve organelle fusion and fission
events. Cells contain different types of peroxisomes that vary in protein composition and …

Rat cDNA encoding a 372-amino-acid peroxin was isolated, primarily by functional
complementation screening, using a peroxisome-deficient Chinese hamster ovary cell …

The regulation of organelle abundance is critical for cell function and survival; however, the
mechanisms responsible are not fully understood. In this study, we characterize a role of the …

Peroxisomes are cell organelles that are present in almost all eukaryotic cells and involved
in a large range of metabolic pathways. The organelles are highly dynamic in nature: their …

To investigate peroxisome assembly and human peroxisome biogenesis disorders (PBDs)
such as Zellweger syndrome, thirteen different complementation groups (CGs) of Chinese …

The question of whether new peroxisomes form autonomously has been a subject of debate
for more than 30 years. In this issue of Cell, Hoepfner et al.(2005) present the most …

A recent report from the Laboratory of Heidi McBride (McGill University) presents a role for
mitochondria in the de novo biogenesis of peroxisomes in mammalian cells. Peroxisomes …

Peroxisomes are single-membraned organelles ubiquitous to eukaryotic cells that house
metabolic reactions that generate and destroy harmful oxidative intermediates. They are …

The long‐standing paradigm that all peroxisomal proteins are imported post‐translationally
into pre‐existing peroxisomes has been challenged by the detection of peroxisomal …

Eukaryotic cells use microtubule-based intracellular transport for the delivery of many
subcellular cargos, including organelles. The canonical view of organelle transport is that …