Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in …

GS Prasath, SP Subramanian - European journal of pharmacology, 2011 - Elsevier
Fisetin (3, 7, 3′, 4′-tetrahydroxyflavone) is a bioflavonoid found in fruits and vegetables. It
exhibits a wide variety of pharmacological properties, including antioxidant, antiinflammatory …

Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats

GS Prasath, SI Pillai, SP Subramanian - European journal of pharmacology, 2014 - Elsevier
Liver plays a vital role in blood glucose homeostasis. Recent studies have provided
considerable evidence that hepatic glucose production (HGP) plays an important role in the …

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

R Murali, S Srinivasan, N Ashokkumar - Biochimie, 2013 - Elsevier
Epidemiological studies have demonstrated that the diabetes mellitus is a serious health
burden for both governments and healthcare providers. The present study was hypothesized …

Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats

GS Prasath, CS Sundaram, SP Subramanian - Endocrine, 2013 - Springer
Persistent hyperglycemia is associated with chronic oxidative stress which contributes to the
development and progression of diabetes-associated complications. The sensitivity of …

Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat

A Narasimhan, M Chinnaiyan… - Applied physiology …, 2015 - cdnsciencepub.com
Ferulic acid (FA) is a phenolic phytochemical known for its antidiabetic property The present
study is designed to evaluate the mechanism behind its antidiabetic property in high-fat and …

Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: a mechanistic study

VP Veerapur, KR Prabhakar, BS Thippeswamy… - Food Chemistry, 2012 - Elsevier
The present study was designed to investigate the effects of the ethanol extract of Ficus
racemosa (FRE) on biochemical parameters in type 2-like diabetes, induced by a …

[PDF][PDF] D-pinitol attenuates the impaired activities of hepatic key enzymes in carbohydrate metabolism of streptozotocin-induced diabetic rats

S Sivakumar, SP Subramanian - General physiology and biophysics, 2009 - academia.edu
During diabetes mellitus, endogenous hepatic glucose production is increasede as a result
of impaired activities of the key enzymes of carbohydrate metabolism, which leads to the …

Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin …

GS Prasath, SP Subramanian - Food and chemical toxicology, 2013 - Elsevier
Oxidative stress is a biological entity quoted as accountable for several pathological
conditions including diabetes mellitus. Chronic hyperglycemia in diabetes is associated with …

Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

R Sundaram, E Nandhakumar… - Toxicology …, 2019 - Taylor & Francis
The present study investigated the protective effect of hesperidin on carbohydrate
metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered …

[HTML][HTML] Pharmacological aspects of fisetin

LD Antika, RM Dewi - Asian Pacific Journal of Tropical …, 2021 - journals.lww.com
Over the past decades, epidemiological studies have concluded that a diet rich in plant-
derived products plays a pivotal role in human health. Fisetin (3, 3', 4', 7 …