Targeted agents in cervical cancer: beyond bevacizumab

G Marquina, A Manzano, A Casado - Current oncology reports, 2018 - Springer
Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women
throughout the world. Approximately two thirds of the patients are diagnosed with locally …

Molecularly targeted therapies in cervical cancer. A systematic review

F Zagouri, TN Sergentanis, D Chrysikos, M Filipits… - Gynecologic …, 2012 - Elsevier
Cervical cancer represents the third most common cause of female cancer mortality. Even
with the best currently available treatment, a significant proportion of patients will experience …

[HTML][HTML] Improved survival with bevacizumab in advanced cervical cancer

KS Tewari, MW Sill, HJ Long III… - … England Journal of …, 2014 - Mass Medical Soc
Background Vascular endothelial growth factor (VEGF) promotes angiogenesis, a mediator
of disease progression in cervical cancer. Bevacizumab, a humanized anti-VEGF …

New molecular targets against cervical cancer

A Duenas-Gonzalez, A Serrano-Olvera… - … journal of women's …, 2014 - Taylor & Francis
Cervical cancer is the third most commonly diagnosed cancer worldwide and the fourth
leading cause of cancer death in women. Major advances but still insufficient achievements …

Cervical cancer–State of the science: From angiogenesis blockade to checkpoint inhibition

LE Minion, KS Tewari - Gynecologic oncology, 2018 - Elsevier
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several
malignancies, including cervical cancer. Chemotherapy doublets combined with the fully …

[HTML][HTML] Emerging biological treatments for uterine cervical carcinoma

P Vici, L Mariani, L Pizzuti, D Sergi, L Di Lauro… - Journal of …, 2014 - ncbi.nlm.nih.gov
Cervical cancer is the third most common cancer worldwide, and the development of new
diagnosis, prognostic, and treatment strategies is a major interest for public health. Cisplatin …

Primary results from CECILIA, a global single-arm phase II study evaluating bevacizumab, carboplatin and paclitaxel for advanced cervical cancer

A Redondo, N Colombo, M McCormack, L Dreosti… - Gynecologic …, 2020 - Elsevier
Objective Adding bevacizumab to cisplatin–paclitaxel for advanced cervical cancer
significantly improves overall and progression-free survival. We evaluated bevacizumab …

Targeting angiogenesis in advanced cervical cancer

RN Eskander, KS Tewari - Therapeutic advances in medical …, 2014 - journals.sagepub.com
Patients with advanced stage or recurrent cervical cancer represent a population with limited
chemotherapeutic options. More specifically, patients with recurrent disease have a poor …

Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic …

KS Tewari, MW Sill, RT Penson, H Huang… - The Lancet, 2017 - thelancet.com
Summary Background On Aug 14, 2014, the US Food and Drug Administration approved the
antiangiogenesis drug bevacizumab for women with advanced cervical cancer on the basis …

Update on novel therapeutic agents for cervical cancer

JM del Campo, A Prat, A Gil-Moreno, J Pérez… - Gynecologic …, 2008 - Elsevier
Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited.
Cisplatin-based combination chemotherapy, the most commonly used cytotoxic therapy, has …