Epilepsy is a neurologicaldisorder characterized by persistent predisposition to recurrent
seizurescaused by abnormal neuronal activity in the brain. Epileptic seizures maydevelop …

Mutations in genes encoding ion channels in brain neurons have been identified in various
epilepsy syndromes. In neuronal networks,“gain-of-function” of channels in excitatory …

Epilepsy is a common neurological disease but the mechanism of seizure generation has
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …

Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with
neuronal hyperexcitability. Apart from the classical imbalance between excitatory …

Idiopathic absence epilepsies (IAE), that have high prevalence particularly among children
and adolescents, are complex disorders mainly caused by genetic factors. Childhood …

Epilepsy is a chronic disease of the central nervous system characterized by an electrical
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …

Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

This work reviews the current knowledge on epileptogenesis and pathophysiology of
epilepsy. Recently, gene defects underlying four monogenic epilepsies (generalized …

Despite recent advances in understanding the causes of epilepsy, especially the genetic,
comprehending the biological mechanisms that lead to the epileptic phenotype remains …

The pathophysiology of epilepsy has been historically grounded on hyperexcitability
attributed to the oversimplified imbalance between excitation (E) and inhibition (I) in the …