This article is a report of the “International Colloquium on Gap junctions: 50 Years of Impact
on Cancer” that was held 8–9 September 2016, at the Amphitheater “Pôle Biologie Santé” of …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Gap junction proteins are expressed in cancer stem cells and non-stem cancer cells of many
tumors. As the morphology and assembly of gap junction channels are crucial for their …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

Intercellular communications are indispensable for the maintenance of homeostasis in the
multicellular organisms. Gap-type junctions are one of the most common and perhaps most …

Cell proliferation is an important process for reproduction, growth and renewal of living cells
and occurs in several situations during life. Cell proliferation is present in all the steps of …

The establishment of gap junctional intercellular communication is a prerequisite for
appropriate control of tissue homeostasis. Gap junctions consist of connexin proteins …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …