Focal cerebral ischemia creates an area of infarction that is surrounded by neuronal tissue
that may respond to nearby damage by creating neurite growth. To determine if axonal …

Neuroanatomical methods have been used to study selective vulnerability after global brain
ischemia. A consistent pattern of ischemic neuronal damage is found in the rodent …

Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus
of the rat hippocampus following removal of specific afferents. In the present study we have …

Background and Purpose Neuroanatomical plasticity is well described in lesions of the
hippocampus but remains a subject of some controversy in the neocortex. The purpose of …

Axonal damage in multiple sclerosis (MS) is correlated to disease progression. Early axonal
damage may be compensated for by regenerative processes. Growth‐associated protein 43 …

In optic fibers, as in most axons of the central nervous system, the axonal growth-associated
protein, GAP-43, is abundant during development but absent in adults. Since optic fibers can …

The neuronal growth-associated protein GAP-43 is expressed during axonal outgrowth and
regeneration (for review, see Benowitz and Routtenberg, 1987). In the present study, we …

Regenerative axon growth in peripheral neurons is accompanied by increased expression
of the growth-associated protein GAP-43. We examined the increase of GAP-43 …

To assess whether ischemia could induce GAP-43 mRNA expression, we performed in situ
hybridization in gerbil brains that had been subjected to 5 min of global ischemia. In control …

It has been postulated that the neuronal growth-associated protein GAP-43 plays an
essential role in axon elongation. Although termination of developmental axon growth is …