Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …

Autophagy is a stress-induced cell survival program whereby cells under metabolic,
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …

Autophagy is being explored as a potential therapeutic target for enhancing the cytotoxic
effects of chemotherapeutic regimens in various malignancies. Autophagy plays a very …

Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Autophagy serves a dichotomous role in cancer and recent advances have helped delineate
the appropriate settings where inhibiting or promoting autophagy may confer therapeutic …

Autophagy is an evolutionarily conserved lysosomal degradation pathway that eliminates
cytosolic proteins, macromolecules, organelles, and protein aggregates. Activation of …

Uncontrolled autophagy has been associated with the development and progression of
various cancers that are resistant to cancer therapy. Therefore, many efforts to modulate …