Apelin interacts with the APJ receptor to enhance inotropy. In heart failure, apelin-APJ
coupling may provide a means of enhancing myocardial function. The alterations in apelin …

The G protein-coupled apelin receptor regulates important processes of the cardiovascular
homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most …

Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart
failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …

Background and purpose: The aim of this study was to determine whether the apelin/APJ
system is altered in human cardiovascular disease by investigating whether the expression …

Background: Apelin, the novel endogenous ligand for the G‐protein‐coupled receptor APJ,
has shown positive inotropic, vasodilatory and diuretic properties in animal studies …

Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …

Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

Background: Apelin and its cognate G protein-coupled receptor, APJ, constitute a signaling
pathway with a positive inotropic effect on cardiac function. Recently, we and other …