Opposing PKA and Hog1 signals control the post‐transcriptional response to glucose availability in Cryptococcus neoformans

D Banerjee, ALM Bloom… - Molecular …, 2016 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans

J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

[HTML][HTML] A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans

AK Stovall, CM Knowles, MC Kalem… - Frontiers in fungal …, 2021 - frontiersin.org
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host

MS Price, M Betancourt-Quiroz, JL Price, DL Toffaletti… - MBio, 2011 - Am Soc Microbiol
Cryptococcus neoformans is an important fungal pathogen of immunocompromised
individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the …

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

G Hu, PY Cheng, A Sham, JR Perfect… - Molecular …, 2008 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian
lung tissue and subsequently disseminates to the brain. We performed serial analysis of …

Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans

ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans

ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Fungi are ubiquitous in the environment and humans constantly encounter them in the soil,
air, water, and food. The vast majority of these interactions are inconsequential. However, in …

Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation

X Xu, J Lin, Y Zhao, E Kirkman, YS So, YS Bahn… - PLoS …, 2017 - journals.plos.org
Morphotype switch is a cellular response to external and internal cues. The Cryptococcus
neoformans species complex can undergo morphological transitions between the yeast and …

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

BJ Chadwick, T Pham, X Xie, LC Ristow, DJ Krysan… - Elife, 2022 - elifesciences.org
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO2 concentrations has only recently been …