Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-
monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size …

Cryptococcus neoformans is a pathogenic basidiomycetous yeast that can cause life-
threatening meningoencephalitis in immuno-compromized patients. To propagate in the …

Metabolic diversity is an important factor during microbial adaptation to different
environments. Among metabolic processes, amino acid biosynthesis has been …

Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …

Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition
(PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain …

The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …

Degradation of the multifunctional amino acid proline is associated with mitochondrial
oxidative respiration. The two-step oxidation of proline is catalyzed by proline oxidase and …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …