Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …

Prochlorococcus is a globally abundant marine cyanobacterium with many adaptations that
reduce cellular nutrient requirements, facilitating growth in its nutrient-poor environment …

Degradation of the multifunctional amino acid proline is associated with mitochondrial
oxidative respiration. The two-step oxidation of proline is catalyzed by proline oxidase and …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Many Gram-positive pathogens link the expression of virulence genes to the presence of
carbon source substrates using overlapping pathways for global control of carbon catabolite …

Functional genomics has become a major focus in the study of microbial pathogenesis. This
study used a functional genomic tool, differential display reverse transcription-PCR, to …

Over the last four decades the HIV pandemic and advances in medical treatments that also
cause immunosuppression have produced an ever-growing cohort of individuals …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …