Nitric oxide synthases, S-nitrosylation and cardiovascular health: from molecular mechanisms to therapeutic opportunities

AV Treuer, DR Gonzalez - Molecular medicine reports, 2015 - spandidos-publications.com
The understanding of nitric oxide (NO) signaling has grown substantially since the
identification of endothelial derived relaxing factor (EDRF). NO has emerged as a ubiquitous …

[图书][B] Nitric oxide and the cardiovascular system

J Loscalzo, JA Vita - 2000 - books.google.com
Leading clinical and experimental investigators comprehensively review the chemistry,
biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the …

Nitric oxide donors as potential drugs for the treatment of vascular diseases due to endothelium dysfunction

M Paulo, DEFR Costa, D Bonaventura… - Current …, 2020 - ingentaconnect.com
Endothelial dysfunction and consequent vasoconstriction are a common condition in
patients with hypertension and other cardiovascular diseases. Endothelial cells produce and …

Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition.

JM Fukuto, G Chaudhuri - Annual review of pharmacology and …, 1995 - europepmc.org
Nitric oxide (NO) is a molecule that has been shown to be involved in a diverse array of
physiological events. A variety of disease states and disorders are, in fact, due to either an …

Nitric oxide as a regulator of inflammatory processes

JL Wallace - Memorias do Instituto Oswaldo Cruz, 2005 - SciELO Brasil
Nitric oxide (NO) plays an important role in mediating many aspects of inflammatory
responses. NO is an effector molecule of cellular injury, and can act as an anti-oxidant. It can …

[PDF][PDF] Current status and future possibilities of nitric oxide-donor drugs: focus on S-nitrosothiols

HH Al-Sa'doni, A Ferro - Mini reviews in medicinal chemistry, 2005 - researchgate.net
Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates
and sodium nitroprusside have been used in cardiovascular therapeutics for many years …

The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - ASPET
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

[HTML][HTML] Nitric oxide—Important messenger in human body

A Martina, P Jana, S Anna, B Tomas - Open journal of molecular and …, 2012 - scirp.org
General idea of this comprehensive review is to summarize information about the role of
nitric oxide in the human body—cardiovascular, respiratory, urgenital, gut, NO and immune …

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

FI Achike, CY Kwan - Clinical and Experimental Pharmacology …, 2003 - Wiley Online Library
Nitric oxide (NO) is formed enzymatically from l‐arginine in the presence of nitric oxide
synthase (NOS). Nitric oxide is generated constitutively in endothelial cells via sheer stress …

Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases

AJ Maxwell - Nitric oxide, 2002 - Elsevier
Vascular nitric oxide (NO) is involved in many physiologic and pathophysiologic processes
throughout the body. Many vascular diseases have a reduction in the activity of endothelium …