Nitric oxide (NO) is a powerful biological mediator provided with a number of activities of
relevance for the prevention of thrombosis, like vasodilation, inhibition of platelet adhesion …

Since its initial discovery as an endogenously produced bioactive mediator, nitric oxide (•
NO) has been found to play a critical role in the cellular function of nearly all organ systems …

The majority of drug discovery research has focused on compounds that interact with the
multitude of receptor systems, primarily at the receptor recognition level, such entities …

Nitric oxide synthase (NOS) inhibitors induce significant vasoconstriction, suggesting an
indispensable role of NO as a local vasodilator. This is due mainly to its effects on large …

Though only recently uncovered as a physiologic messenger, nitric oxide (NO) is
increasingly appreciated as a major regulator in the nervous, immune, and cardiovascular …

In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the
introduction of nitrate‐containing compounds for medicinal purposes marked its 150th …

Michael A. Marietta received his AB degree in chemistry from the State Universityof New
York, College at Fredonia, and his Ph. D. in Pharmaceutical Chemistry from the University of …

Nitric oxide (NO) is just one member of a new class of gaseous signalling molecules with
fundamental actions in biology. In higher vertebrates it has key roles in maintaining …

Beyond an inert oxidation product of nitric oxide (NO) metabolism, current thinking posits a
key role for nitrite as a mediator of NO signaling, especially during hypoxia. This concept has …

Publisher Summary This chapter discusses some of the biologically relevant chemistry of
nitric oxide (NO) as a preface to an understanding its physiological and pathophysiological …