Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1

U Sivagnanam, S Narayana Murthy, SN Gummadi - BMC biochemistry, 2016 - Springer
Background Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca
2+ dependent phospholipid translocator involved in disrupting membrane asymmetry …

Phospholipid scramblase 1.

Y Huang, Q Zhao, GQ Chen - Sheng li xue bao:[Acta Physiologica …, 2006 - europepmc.org
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II
endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import …

Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells

Y Huang, Q Zhao, CX Zhou, ZM Gu, D Li, HZ Xu… - Oncogene, 2006 - nature.com
Abstract Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated protein which is
localized in either the cell membrane or nucleus depending on its palmitoylated state. The …

[HTML][HTML] Identification of three new members of the phospholipid scramblase gene family

T Wiedmer, Q Zhou, DY Kwoh, PJ Sims - Biochimica et Biophysica Acta …, 2000 - Elsevier
Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced
bidirectional transbilayer movement of plasma membrane phospholipids in activated …

Two c-Myc binding sites are crucial in upregulating the expression of human phospholipid scramblase 1 gene

JM Vinnakota, SN Gummadi - Biochemical and biophysical research …, 2016 - Elsevier
Abstract Human phospholipid scramblase 1 (hPLSCR1) is a type II endofacial membrane
protein which mediates bi-directional transport of phospholipids across the plasma …

Biophysical characterization of the DNA binding motif of human phospholipid scramblase 1

S Rayala, U Sivagnanam, SN Gummadi - European Biophysics Journal, 2022 - Springer
Abstract Human phospholipid scramblase 1 (hPLSCR1) is a 37 kDa multi-compartmental
protein, which was initially identified as a Ca2+-dependent phospholipid translocator upon …

In vitro reconstitution and biochemical characterization of human phospholipid scramblase 3: phospholipid specificity and metal ion binding studies

SK Palanirajan, U Sivagnanam, S Murugan… - Biological …, 2018 - degruyter.com
Abstract Human phospholipid scramblase 3 (hPLSCR3) is a single pass transmembrane
protein that plays a vital role in fat metabolism, mitochondrial function, structure …

RNA interference‑mediated downregulation of phospholipid scramblase 1 expression in primary liver cancer in vitro

L Gui, YW Zhu, Q Xu, JJ Huang, P Hua… - Oncology …, 2020 - spandidos-publications.com
Abstract Phospholipid scramblase 1 (PLSCR1) serves a function in the pathogenesis and
progression of various types of cancer. However, the role of PLSCR1 in human primary liver …

Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

J Dal Col, MJ Lamberti, A Nigro, V Casolaro… - Cell Communication and …, 2022 - Springer
Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4)

VG Francis, SN Gummadi - Biological Chemistry, 2012 - degruyter.com
Abstract Human phospholipid scramblase 4 (hPLSCR4), an isoform of the scramblase
family, is a type II single-pass transmembrane protein whose function remains unknown. To …