The activation of specific cytosolic pathogen recognition receptors, the nucleotide‐binding‐
oligomerization‐domain‐(NOD‐) like receptors (NLRs), leads to the assembly of the …

Colorectal cancer is a major health problem in developed countries. Chronic intestinal
inflammation predisposes individuals to the development of colorectal cancer. The …

Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which
promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and …

Inflammasomes are a large family of multiprotein complexes recognizing pathogen-
associated molecular pattern molecules (PAMPs) and damage-associated molecular …

Inflammasomes are intracellular multiprotein complexes that coordinate the maturation of
interleukin (IL)‐1β and IL‐18 in response to pathogens and metabolic danger. Both …

Recent advances have revealed significant insight into inflammatory bowel disease (IBD)
pathobiology. Ulcerative colitis and Crohn's disease, the chronic relapsing clinical …

Pattern recognition receptors (PRR), such as NOD-like receptors (NLRs), sense conserved
microbial signatures, and host danger signals leading to the coordination of appropriate …

The mammalian intestinal tract harbors a vast and diverse ecosystem of microbes that are
separated from the sterile host milieu by a single layer of epithelial cells. While this bio …

Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-
containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible …

Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute
a major health problem in developed countries. Moreover, IBD predisposes to the …