Toxicogenomics is the study of the molecular effects of chemical, biological and physical
agents in biological systems, with the aim of elucidating toxicological mechanisms, building …

Assessing the drug safety at an early stage of a drug discovery program is a critical issue.
With the recent advances in molecular biology and genomic, massive amounts of generated …

The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in
order to study systems-level responses to compound treatments. In recent years there has …

Despite investment in toxicogenomics, nonclinical safety studies are still used to predict
clinical liabilities for new drug candidates. Network-based approaches for genomic analysis …

Background Methods for inference and comparison of biological networks are emerging as
powerful tools for the identification of groups of tightly connected genes whose activity may …

Introduction: While targeted investigation of key toxicity pathways has been instrumental for
biomarker discovery, unbiased and holistic analysis of transcriptomic data provides a …

Although microarray technology has emerged as a powerful tool to explore expression
levels of thousands of genes or even complete genomes after exposure to toxicants, the …

Background During the last few years, the knowledge of drug, disease phenotype and
protein has been rapidly accumulated and more and more scientists have been drawn the …

A systems-level understanding of molecular perturbations is crucial for evaluating chemical-
induced toxicity risks appropriately, and for this purpose comprehensive gene expression …

The computational prediction of compound effects from molecular data is an important task
in hazard and risk assessment and pivotal for judging the safety of any drug, chemical or …