Loss of caspase-8 expression–which has been demonstrated in a subset of
Medulloblastoma (MB)–might block important apoptotic signalling pathways and therefore …

Purpose: Escaping apoptosis is a hallmark of cancer. In medulloblastoma (MB) cell lines,
resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis was …

Loss of caspase-8 expression and resistance to cytotoxic agents occurs frequently in late
stage neuroblastoma (NB). Interferon-γ (IFN-γ) induces caspase-8 in NB cells, sensitizing …

Caspase-8 was originally identified as a central player of programmed cell death triggered
by death receptor stimulation. In that context, its activity is tightly regulated through several …

It is well known that caspase-8 is an 'initiator'caspase acting at the top of the apoptotic
cascade. 1–3 Specific ligand engagement by death receptors of the TNF-R superfamily or …

Glioblastoma multiforme, the most common brain tumor, typically exhibits markedly
increased angiogenesis, which is crucial for tumor growth and invasion. Antiangiogenic …

BACKGROUND: The expression of caspase-8, a cysteine protease that is crucial for the
apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent …

Medulloblastoma (MB) is a high-grade pediatric brain malignancy that originates from
neuronal precursors located in the posterior cranial fossa. In this study, we evaluated the …

Interferon (IFN)-β is known to exert cytostatic or cytocidal effects in human glioma cells and
is widely used in the treatment for gliomas. However, precise mechanisms of cell death …

Medulloblastoma is the most common malignant paediatric brain tumour, representing 20%
of all paediatric intercranial tumours. Current aggressive treatment protocols and the use of …