INTRODUCTION The drive to seek and experience reward is conserved across species and,
in mammals, involves interactions between subcortical dopaminergic systems and limbic …

Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core symptom of
major depressive disorder that may reflect an underlying dysregulation in reward …

Stimulus-reward coupling without attention can induce highly specific perceptual learning
effects, suggesting that reward triggers selective plasticity within visual cortex. Additionally …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Anhedonia is a core symptom of depression, but the underlying neurobiological
mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within …

Highlights•Dysfunctional reward processing is central to the pathophysiology of depression.•
Behavioral impairments in depression vary across reward sub-processes.•A distributed …

Many neuroimaging studies have investigated reward processing dysfunction in major
depressive disorder. These studies have led to the common idea that major depressive …

The medial prefrontal cortex (mPFC) plays a critical role in multiple cognitive and limbic
functions. Given its vital importance, investigating the function of individual mPFC circuits in …

Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful
experiences precipitate depression and disrupt reward-seeking, but it remains unclear how …

INTRODUCTION Acting to achieve goals underlies animals' behavioral flexibility and
depends on the ability to motivate specific behaviors. Formal studies of goal-directed …