A sensitive and selective liquid chromatographic tandem mass spectrometric method was
developed and validated for the determination of sinomenine in human plasma. Plasma …

A RP-HPLC method was developed to determine the concentrations of sinomenine HCl in
serum and urine and its pharmacokinetics was studied in healthy volunteers. C18H37 …

Aim: To improve and validate analytical methods based on HPLC and liquid
chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI …

A simple HPLC method has been developed for determination of sinomenine in dog plasma
and has been used to evaluate the pharmacokinetics of sinomenine tablets in dogs …

BACKGROUND: Sinomenine is a pure alkaloid with a variety of pharmacological actions
including anti-inflammation, immuno-suppression, analgesia, antihypertension, and …

[Pharmacokinetics of sinomenine by HPLC]. - Abstract - Europe PMC Sign in | Create an
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Objective To study pharmacokinetic parameters and absolute bioavailability for oral use of
sinomenine tablet in beagle dogs. Method Applying to double cycle self crossover design, a …

A sensitive, precise and selective ultra-high performance liquid chromatography method
coupled with triple-quadrupole mass spectrometry was developed and validated for the …

AIM: To investigate the effect of release behavior of sustained-release dosage forms of
sinomenine hydrochloride (SM• HCl) on its pharmacokinetics in beagle dogs. METHODS …

Various products containing sinomenine monomer and extracts of Sinomenium acutum
have been widely applied in clinical treatments. The goal of the present study was to …