Objective The aim of this study was to evaluate the bioequivalence between the generic
(test) formulation containing tianeptine sodium 12.5 mg and the branded (reference) …

Two thousand three hundred and thirty five plasma concentrations of tianeptine from 112
patients enrolled in nine studies of tianeptine pharmacokinetics performed prior to the …

The predictive ability of population pharmacokinetic parameters of tianeptine, obtained from
a mixed effect analysis of pre-marketing pharmacokinetic studies, was evaluated using …

A new, selective and sensitive high-performance liquid chromatography (HPLC) method
with fluorimetric detection was developed for the determination of tianeptine (TIA) in human …

An improved analytical method for the quantitative measurement of tianeptine and its main
metabolite MC5 in human plasma was designed. Extraction involved ion-paired liquid–liquid …

Following oral administration in the fasting healthy subject, the mean maximum
concentration of tianeptine is 334+/-79 ng/ml. Absorption of tianeptine from the tablet form is …

Tianeptine is a new antidepressant, structurally related to the tricyclic antidepressants. One
of its main neurochemical effects is to increase serotonin uptake (Kato & Weitsch 1988; …

Introduction: Coaxil (tianeptine) is a new generation antidepressant with selective
serotoninergic action. Recently, a significant increase in non-medical use of the atypical …

A balanced 3 way cross‐over study involving 12 young healthy volunteers (6 men and 6
women) was used to determine the pharmacokinetic parameters of the antidepressant …

A sensitive and selective high-performance liquid chromatographic method has been
developed for the determination of tianeptine (Tia) in tablets. The method is based on …