mAbs constitute an important biological tool for influenza virus haemagglutinin (HA) epitope
mapping through the generation of escape mutants, which could provide insights into …

Murine hybridomas producing neutralizing mAbs specific to the pandemic influenza virus
A/California/07/2009 haemagglutinin (HA) were isolated. These antibodies recognized at …

Aims and Methods To facilitate antigenic characterization of the influenza A 2009 pandemic
H1N1 [A (H1N1) pdm09] hemagglutinin (HA), we generated a panel of murine monoclonal …

The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and
characterized three human monoclonal antibodies (mAbs) that neutralize A (H1N1) pdm09 …

We determined the antigenic structure of pandemic influenza A (H1N1) pdm09 virus
hemagglutinin (HA) using 599 escape mutants that were selected using 16 anti-HA …

Seasonal epidemics caused by antigenic variations in influenza A virus remain a public
health concern and an economic burden. The isolation and characterization of broadly …

Influenza virus evades host immunity through antigenic drift and shift, and continues to
circulate in the human population causing periodic outbreaks including the recent 2009 …

Due to continuous changes to its antigenic regions, influenza viruses can evade immune
detection and cause a significant amount of morbidity and mortality around the world …

The induction of neutralising antibodies to the viral surface glycoprotein, haemagglutinin
(HA) is considered the cornerstone of current seasonal and pandemic influenza vaccines …

Circulating influenza viruses evade neutralization in their human hosts by acquiring escape
mutations at epitopes of prevalent antibodies. A goal for next-generation influenza vaccines …