Muscle fatigue is a reduction in the capacity to exert force and may involve a “central”
component originating in the brain and/or spinal cord. Here we examined whether …

The excitability of the motor cortex increases as fatigue develops during sustained single-
joint contractions, but there are no previous reports on how corticospinal excitability is …

Exercise-induced fatigue influences the excitability of the motor pathway during single-joint
isometric contractions. This study sought to investigate the influence of fatigue on …

This study sought to determine whether afferent feedback associated with peripheral muscle
fatigue inhibits central motor drive (CMD) and thereby limits endurance exercise …

Magnetic and electrical stimulation at different levels of the neuraxis show that supraspinal
and spinal factors limit force production in maximal isometric efforts (“central fatigue”). In …

Over the last two decades, an abundance of research has explored the impact of fatiguing
locomotor exercise on the neuromuscular system. Neurostimulation techniques have been …

Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force. It may
arise not only because of peripheral changes at the level of the muscle, but also because …

There is substantial evidence that fatiguing exercise is accompanied by changes within the
central nervous system that reduce the force that can be produced by working muscles. Here …

This review aims to characterize fatigue-related changes in corticospinal excitability and
inhibition in healthy subjects. Transcranial magnetic stimulation (TMS) has been extensively …

During maximal exercise, supraspinal fatigue contributes significantly to the decline in
muscle performance but little is known about intracortical inhibition during such contractions …