Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …

In previous studies, we determined that the F-box protein Fbp1, a subunit of the SCF (Fbp1)
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …

Cryptococcus neoformans is the main etiologic agent of cryptococcal meningitis and causes
a significant number of deadly infections per year. Although it is well appreciated that host …

Cryptococcus neoformans is a major etiological agent of fungal meningoencephalitis. The
outcome of cryptococcosis depends on the complex interactions between the pathogenic …

Deletions of cryptococcal PIK1, RUB1, and ENA1 genes independently rendered defects in
yeast survival in human CSF and within macrophages. We evaluated virulence potential of …

Numerous virulence factors expressed by Cryptococcus neoformans modulate host
defenses by promoting nonprotective Th2-biased adaptive immune responses. Prior studies …

The basidiomycete fungus Cryptococcus neoformans is a useful model for investigating
mechanisms of fungal pathogenesis in mammalian hosts. This pathogen is the causative …

Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal
pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis …